The DHRS7–OXER1 pathway links oxidative stress to immunity and tissue resilience by modulating 5-oxoETE via NADP+–NADPH, activating OXER1 to recruit antimicrobial cells and induce NUDIX enzymes that protect epithelial redox integrity.
The DHRS7–OXER1 pathway links oxidative stress to immunity and tissue resilience by modulating 5-oxoETE via NADP+–NADPH, activating OXER1 to recruit antimicrobial cells and induce NUDIX enzymes that protect epithelial redox integrity.